A time crystal is a time dependent physical system that does not reach a standstill, even in state of minimum energy. Here we show that the stability of a time crystal can be enhanced by its topology. For this we simulate time crystals made of chainlike ensembles of mutually interacting point particles. When we tie the chain into a knot we find that its timecrystalline qualities improve. The theoretical models we consider are widely used in coarse grained descriptions of linear polymers. Thus we expect that physical realizations of time crystals can be found in terms of knotted molecules.